Structure of PDB 4f0r Chain A

Receptor sequence
>4f0rA (length=436) Species: 243365 (Chromobacterium violaceum ATCC 12472) [Search protein sequence]
RYEKIISARWIITVETDGEVLENHAIAIRDGKIAAIIPAADAAGLEADER
LELPDHVLMPGLINLHGHSAMSLLRGLADDKALMDWLTNYIWPTEGKHVH
DDFVFDGSLLAMGEMIRGGTTTINDMYFYNAAVARAGLASGMRTFVGCSI
LEFPTNYASNADDYIAKGMAERSQFLGEDLLTFTLAPHAPYTVSDDTFRK
VVTLAEQEDMLIHCHIHETADEVNNSVKEHGQRPLARLQRLGLLSPRLVA
AHMVHLNDAEVELAARHGLSTAHNPASNMKLASGISPVSKLMDAGVAVGI
GTDGAASNNKLDMLAETRLAALLAKVGTLDPTSVPAAAAIRMATLNGARA
LGIADKVGSVKVGKQADLIALDLAQLETAPAFDPISHVVYAAGREQVSHV
WVKGRALMRERKLTTLDESDLKARAGDWRNRILAKE
3D structure
PDB4f0r Crystal structure of an adenosine deaminase homolog from Chromobacterium violaceum (target NYSGRC-019589) bound Zn and 5'-Methylthioadenosine (unproductive complex)
ChainA
Resolution1.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.5.4.28: S-adenosylhomocysteine deaminase.
3.5.4.31: S-methyl-5'-thioadenosine deaminase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H70 H72 H219 D307 H66 H68 H215 D303
BS02 MTA A H72 W96 E99 F132 S153 F157 H192 H68 W92 E95 F128 S149 F153 H188
Gene Ontology
Molecular Function
GO:0004000 adenosine deaminase activity
GO:0016787 hydrolase activity
GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
GO:0019239 deaminase activity
GO:0046872 metal ion binding
GO:0050270 S-adenosylhomocysteine deaminase activity
GO:0090614 5'-methylthioadenosine deaminase activity

View graph for
Molecular Function
External links
PDB RCSB:4f0r, PDBe:4f0r, PDBj:4f0r
PDBsum4f0r
PubMed
UniProtQ7NZ90

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