Structure of PDB 4ezh Chain A

Receptor sequence
>4ezhA (length=455) Species: 10090 (Mus musculus) [Search protein sequence]
ESYLSPAQSVKPKINTEEKLPREKLNPPTPSIYLESKRDAFSPVLLQFCT
DPRNPITVIRGLAGSLRLNLGLFSTKTLVEASGEHTVEVRTQVQQPSDEN
WDLTGTRQIWPCESSRSHTTIAKYAQYQASSFQESLQEELEVLFQHHIIK
FGTNIDLSDAKRWKPQLQELLKLPAFMRVTSTGNMLSHVGHTILGMNTVQ
LYMKVPGSRTPGHQENNNFCSVNINIGPGDCEWFAVHEHYWETISAFCDR
HGVDYLTGSWWPILDDLYASNIPVYRFVQRPGDLVWINAGTVHWVQATGW
CNNIAWNVGPLTAYQYQLALERYEWNEVKNVKSIVPMIHVSWNVARTVKI
SDPDLFKMIKFCLLQSMKHCQVQRESLVRAGKKIAYQGRVKDEPAYYCNE
CDVEVFNILFVTSTYLVHCEGCARRRSAGLQGVVVLEQYRTEELAQAYDA
FTLAP
3D structure
PDB4ezh A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response.
ChainA
Resolution2.52 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 1.14.11.68: [histone H3]-trimethyl-L-lysine(27) demethylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A E1244 R1246 E1269 S1270 R1272 N1331 D1333 L1371 G1372 Q1377 Y1379 E1392 G1435 A1482 W1483 N1484 E88 R90 E113 S114 R116 N154 D156 L194 G195 Q200 Y202 E215 G258 A305 W306 N307
BS02 ZN A C1575 C1578 C1602 C1605 C398 C401 C419 C422
External links
PDB RCSB:4ezh, PDBe:4ezh, PDBj:4ezh
PDBsum4ezh
PubMed22842901
UniProtQ5NCY0|KDM6B_MOUSE Lysine-specific demethylase 6B (Gene Name=Kdm6b)

[Back to BioLiP]