Structure of PDB 4ev5 Chain A

Receptor sequence

>4ev5A (length=654) Species: 870730 (Ogataea angusta)

PARPAHPLDPLSTAEIKAATNTVKSYFAGKKISFNTVTLREPARKAYIQW
KEQGGPLPPRLAYYVILEAGKPGVKEGLVDLASLSVIETRALETVQPILT
VEDLCSTEEVIRNDPAVIEQCVLSGIPANEMHKVYCDPWTIGYDERWGTG
KRLQQALVYYRSDEDDSQYSHPLDFCPIVDTEEKKVIFIDIPNRRRKVSK
HKHANFYPKHMIEKVGAMRPEAPPINVTQPEGVSFKMTGNVMEWSNFKFH
IGFNYREGIVLSDVSYNDHGNVRPIFHRISLSEMIVPYGSPEFPHQRKHA
LDIGEYGAGYMTNPLSLGCDCKGVIHYLDAHFSDRAGDPITVKNAVCIHE
EDDGLLFKHSDFRDNFATSLVTRATKLVVSQIFTAANYEYCLYWVFMQDG
AIRLDIRLTGILNTYILGDDEEAGPWGTRVYPNVNAHNHQHLFSLRIDPR
IDGDGNSAAACDAKSSPYPLGSPENMYGNAFYSEKTTFKTVKDSLTNYES
ATGRSWDIFNPNKVNPYSGKPPSYKLVSTQCPPLLAKEGSLVAKRAPWAS
HSVNVVPYKDNRLYPSGDHVPQWSGDGVRGMREWIGDGSENIDNTDILFF
HTFGITHFPAPEDFPLMPAEPITLMLRPRHFFTENPGLDIQPSYAMTTSE
AKRA

3D structure

• PDB: 4ev5 Crystal structure of copper amine oxidase-1 from Hansenula polymorpha in complex with benzylamine
• Chain: A
• Resolution: 2.25 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): Y305 D319 Y405 H456 H458 H624
• Catalytic site (residue number reindexed from 1): Y288 D302 Y388 H439 H441 H607
• Enzyme Commision number: 1.4.3.21: primary-amine oxidase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	CU	A	H456 H458 H624	H439 H441 H607
BS02	ABN	A	W156 A317 D319 Y323 A402 A403 Y405	W139 A300 D302 Y306 A385 A386 Y388

Gene Ontology

Molecular Function

• GO:0005507 copper ion binding
• GO:0008131 primary methylamine oxidase activity
• GO:0016491 oxidoreductase activity
• GO:0046872 metal ion binding
• GO:0048038 quinone binding
• GO:0052595 aliphatic amine oxidase activity

Biological Process

• GO:0009308 amine metabolic process

Cellular Component

• GO:0005777 peroxisome

External links

• PDB: RCSB:4ev5, PDBe:4ev5, PDBj:4ev5
• PDBsum: 4ev5
• UniProt: P12807|AMO_PICAN Peroxisomal primary amine oxidase (Gene Name=AMO)