Structure of PDB 4etw Chain A

Receptor sequence
>4etwA (length=255) Species: 623 (Shigella flexneri) [Search protein sequence]
NIWWQTKGQGNVHLVLLHGWGLNAEVWRCIDEELSSHFTLHLVDLPGFGR
SRGFGALSLADMAEAVLQQAPDKAIWLGWALGGLVASQIALTHPERVQAL
VTVASSPCFSARDEWPGIKPDVLAGFQQQLSDDFQRTVERFLALQTMGTE
TARQDARALKKTVLALPMPEVDVLNGGLEILKTVDLRQPLQNVSMPFLRL
YGYLDGLVPRKVVPMLDKLWPHSESYIFAKAAHAPFISHPAEFCHLLVAL
KQRVL
3D structure
PDB4etw Structure of the enzyme-acyl carrier protein (ACP) substrate gatekeeper complex required for biotin synthesis.
ChainA
Resolution2.05 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.1.85: pimeloyl-[acyl-carrier protein] methyl ester esterase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZMK A G21 W22 A82 L83 V124 F128 F143 L183 H235 G19 W20 A80 L81 V122 F126 F141 L181 H233
Gene Ontology
Molecular Function
GO:0052689 carboxylic ester hydrolase activity
GO:0090499 pimelyl-[acyl-carrier protein] methyl ester esterase activity
Biological Process
GO:0009102 biotin biosynthetic process
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4etw, PDBe:4etw, PDBj:4etw
PDBsum4etw
PubMed23045647
UniProtQ83PW0|BIOH_SHIFL Pimeloyl-[acyl-carrier protein] methyl ester esterase (Gene Name=bioH)

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