Structure of PDB 4esj Chain A

Receptor sequence
>4esjA (length=246) Species: 170187 (Streptococcus pneumoniae TIGR4) [Search protein sequence]
PHMELHFNLELVETYKSNSQKARILTEDWVYRQSYCPNCGNNPLNHFPVA
DFYCNHCSEEFELKSKKGNFSSTINDGAYATMMKRVQADNNPNFFFLTYT
KNFEVNNFLVLPKQFVTPKSIIQRKPLAGWIGCNIDLSQVPSKGRIFLVQ
DGQVRDPEKVTKEFKQGLFLRKSSLSSRGWTIEILNCIDKIEGSEFTLED
MYRFESDLKNIFVKNNHIKEKIRQQLQILRDKEIIEFKGRGKYRKL
3D structure
PDB4esj Crystal structure and mechanism of action of the N6-methyladenine-dependent type IIM restriction endonuclease R.DpnI.
ChainA
Resolution2.05 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.21.4: type II site-specific deoxyribonuclease.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A L206 R231 Q232 Q235 R238 F245 G249 Y251 L198 R223 Q224 Q227 R230 F237 G241 Y243
BS02 dna A S182 S184 S185 K222 N223 N224 H225 E228 K229 Q232 S174 S176 S177 K214 N215 N216 H217 E220 K221 Q224
BS03 ZN A C34 C37 C56 C59 C36 C39 C54 C57
BS04 ZN A E2 H4 E4 H6
BS05 AZI A N6 D26 R30 N8 D28 R32
Gene Ontology
Molecular Function
GO:0004519 endonuclease activity
GO:0009036 type II site-specific deoxyribonuclease activity
Biological Process
GO:0009307 DNA restriction-modification system

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Molecular Function
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Biological Process
External links
PDB RCSB:4esj, PDBe:4esj, PDBj:4esj
PDBsum4esj
PubMed22610857
UniProtP0A460|T2D1_STRR6 Type II Methyl-directed restriction enzyme DpnI (Gene Name=dpnC)

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