Structure of PDB 4esi Chain A

Receptor sequence
>4esiA (length=261) Species: 3988 (Ricinus communis) [Search protein sequence]
QYPIINFTTAGATVQSYTNFIRAVRGRLTTGADVRHEIPVLPNRVGLPIN
QRFILVELSNHAELSVTLALDVTNAYVVGYRAGNSAYFFHPDNQEDAEAI
THLFTDVQNRYTFAFGGNYDRLEQLAGNLRENIELGNGPLEEAISALYYY
STGGTQLPTLARSFIICIQMISEAARFQYIEGEMRTRIRYNRRSAPDPSV
ITLENSWGRLSTAIQESNQGAFASPIQLQRRNGSKFSVYDVSILIPIIAL
MVYRCAPPPSS
3D structure
PDB4esi Optimized 5-membered heterocycle-linked pterins for the inhibition of Ricin Toxin A.
ChainA
Resolution1.87 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) V81 E177 R180
Catalytic site (residue number reindexed from 1) V77 E173 R176
Enzyme Commision number 3.2.2.22: rRNA N-glycosylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 0RB A Y80 V81 G121 N122 Y123 I172 R180 Y76 V77 G117 N118 Y119 I168 R176 MOAD: ic50=70uM
PDBbind-CN: -logKd/Ki=4.15,IC50=70uM
Gene Ontology
Molecular Function
GO:0030598 rRNA N-glycosylase activity
Biological Process
GO:0017148 negative regulation of translation

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Molecular Function
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Biological Process
External links
PDB RCSB:4esi, PDBe:4esi, PDBj:4esi
PDBsum4esi
PubMed23050058
UniProtP02879|RICI_RICCO Ricin

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