Structure of PDB 4erf Chain A

Receptor sequence
>4erfA (length=92) Species: 9606 (Homo sapiens) [Search protein sequence]
IPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYD
EKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVV
3D structure
PDB4erf Structure-based design of novel inhibitors of the MDM2-p53 interaction.
ChainA
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 0R3 A L54 I61 Y67 V93 K94 H96 I99 Y100 L36 I43 Y49 V75 K76 H78 I81 Y82 MOAD: Kd=0.4nM
PDBbind-CN: -logKd/Ki=9.40,Kd=0.4nM
BindingDB: Kd=0.4nM,IC50=4.1nM
Gene Ontology
Biological Process
GO:0043066 negative regulation of apoptotic process
GO:0051726 regulation of cell cycle
Cellular Component
GO:0005634 nucleus

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Biological Process
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Cellular Component
External links
PDB RCSB:4erf, PDBe:4erf, PDBj:4erf
PDBsum4erf
PubMed22524527
UniProtQ00987|MDM2_HUMAN E3 ubiquitin-protein ligase Mdm2 (Gene Name=MDM2)

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