Structure of PDB 4ere Chain A

Receptor sequence
>4ereA (length=85) Species: 9606 (Homo sapiens) [Search protein sequence]
SEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYHIVY
CSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVN
3D structure
PDB4ere Structure-based design of novel inhibitors of the MDM2-p53 interaction.
ChainA
Resolution1.8 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 0R2 A L54 I61 V93 K94 H96 I99 L33 I40 V67 K68 H70 I73 MOAD: ic50=4.2nM
PDBbind-CN: -logKd/Ki=8.38,IC50=4.2nM
Gene Ontology
Biological Process
GO:0043066 negative regulation of apoptotic process
GO:0051726 regulation of cell cycle
Cellular Component
GO:0005634 nucleus

View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:4ere, PDBe:4ere, PDBj:4ere
PDBsum4ere
PubMed22524527
UniProtQ00987|MDM2_HUMAN E3 ubiquitin-protein ligase Mdm2 (Gene Name=MDM2)

[Back to BioLiP]