Structure of PDB 4equ Chain A

Receptor sequence
>4equA (length=274) Species: 9606 (Homo sapiens) [Search protein sequence]
EHVRRDLDPNEVWEIVGELGKVYKAKNKETGALAAAKVIELEDYIVEIEI
LATCDHPYIVKLLGAYYHDGKLWIMIEFCPGGAVDAIMLELDRGLTEPQI
QVVCRQMLEALNFLHSKRIIHRDLKAGNVLMTLEGDIRLADFGVSAKNLI
GTPYWMAPEVVMCETMKDTPYDYKADIWSLGITLIEMAQIEPPHHELNPM
RVLLKIAKSDPPTLLTPSKWSVEFRDFLKIALDKNPETRPSAAQLLEHPF
VSSITSNKALRELVAEAKAEVMEE
3D structure
PDB4equ Affinity-Based Probes Based on Type II Kinase Inhibitors.
ChainA
Resolution2.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D157 K159 G161 N162 D175 T195
Catalytic site (residue number reindexed from 1) D123 K125 G127 N128 D141 T152
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 G6I A V50 A63 E81 L85 V94 I110 F112 C113 L164 A174 D175 F176 V22 A35 E47 L51 V60 I76 F78 C79 L130 A140 D141 F142
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4equ, PDBe:4equ, PDBj:4equ
PDBsum4equ
PubMed23088519
UniProtO94804|STK10_HUMAN Serine/threonine-protein kinase 10 (Gene Name=STK10)

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