Structure of PDB 4eq5 Chain A

Receptor sequence
>4eq5A (length=516) Species: 604354 (Thermococcus sibiricus MM 739) [Search protein sequence]
SLYKELVELYKRLEKTTLKTLKTKFVSDFLKSVEKPELLEVIPYLILGKV
FPDWDERELGILLIKAVSTIERVYNTLVKIAEASGAGSQDRKLKYLANLF
MDASPDEGKYLARTVLGIMRTGVAEGLLRDALADAFKVRVELVERAYMLT
SDFGFVAKVAKLEGDEGLAKVKIQVGKPIKPMLAQMAANVREALVEMGGE
AEFEIKYDGARVQVHKNGNKVLIYSRRLENVTKSIPEVVERVKEALKPEK
VIVEGELVAVEETGRPRPFQYVLRRFRRKYNIEEMIEKIPLELNLFDILY
VDGQNMIDTPFMERRKVLESVVNSNEWIKSAENLITKSPEEAEAFYHKAL
DLGHEGLMAKRLDSTYEPGNRGKKWLKIKPTMENLDLVVLGAEWGEGRRS
GVLSSFLLGAYDPVKGDFVPVGKVGSGFTDEDLVEFTKMLKPLIKKEHGK
EVELEPKVVIEVAYQEIQKSPKYESGFALRFPRYIALREDKGPEDADTVQ
RLAELYQFQERLKGGR
3D structure
PDB4eq5 Expression, purification, crystallization and preliminary crystallographic analysis of a thermostable DNA ligase from the archaeon Thermococcus sibiricus.
ChainA
Resolution2.85 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 6.5.1.6: DNA ligase (ATP or NAD(+)).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AMP A L238 E259 K261 Y262 R266 R281 E311 F351 K415 R426 K432 L183 E204 K206 Y207 R211 R226 E256 F296 K360 R371 K377
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003909 DNA ligase activity
GO:0003910 DNA ligase (ATP) activity
GO:0005524 ATP binding
GO:0016874 ligase activity
GO:0046872 metal ion binding
Biological Process
GO:0006260 DNA replication
GO:0006266 DNA ligation
GO:0006273 lagging strand elongation
GO:0006281 DNA repair
GO:0006310 DNA recombination
GO:0051301 cell division
GO:0071897 DNA biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:4eq5, PDBe:4eq5, PDBj:4eq5
PDBsum4eq5
PubMed22297989
UniProtC6A2U9

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