Structure of PDB 4eq0 Chain A

Receptor sequence
>4eq0A (length=198) Species: 11685 (HIV-1 M:B_ARV2/SF2) [Search protein sequence]
PQITLWKRPLVTIRIGGQLKEALLNTGSDFTVLEEMNLPGKWKPKMIRGI
GGFIKVRQYDQIPVEILGHKAIGTVLVGPTPVNIIGRNLLTQIGMTLNFP
QITLWKRPLVTIRIGGQLKEALLNTGSDDTVLEEMNLPGKWKPKMIGGIG
GFIKVRQYDQIPVEILGHKAIGTVLVGPTPVNIIGRNLLTQIGMTLNF
3D structure
PDB4eq0 Structural, kinetic, and thermodynamic studies of specificity designed HIV-1 protease.
ChainA
Resolution1.7 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) N125 T126 G127
Catalytic site (residue number reindexed from 1) N124 T125 G126
Enzyme Commision number 2.7.7.-
2.7.7.49: RNA-directed DNA polymerase.
2.7.7.7: DNA-directed DNA polymerase.
3.1.-.-
3.1.13.2: exoribonuclease H.
3.1.26.13: retroviral ribonuclease H.
3.4.23.16: HIV-1 retropepsin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A R8 L23 N25 G27 S28 D29 F30 I47 R48 V82 I84 N125 G127 S128 D129 D130 P181 R8 L23 N25 G27 S28 D29 F30 I47 R48 V82 I84 N124 G126 S127 D128 D129 P180
Gene Ontology
Molecular Function
GO:0004190 aspartic-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:4eq0, PDBe:4eq0, PDBj:4eq0
PDBsum4eq0
PubMed22549928
UniProtP03369|POL_HV1A2 Gag-Pol polyprotein (Gene Name=gag-pol)

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