Structure of PDB 4epy Chain A

Receptor sequence
>4epyA (length=170) Species: 9606 (Homo sapiens) [Search protein sequence]
GMTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGE
TCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQ
IKRVKDSEDVPMVLVGNKSDLPSRTVDTKQAQDLARSYGIPFIETSAKTR
QGVDDAFYTLVREIRKHKEK
3D structure
PDB4epy Discovery of Small Molecules that Bind to K-Ras and Inhibit Sos-Mediated Activation.
ChainA
Resolution1.801 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GDP A G13 V14 G15 K16 S17 A18 F28 D30 N116 K117 D119 L120 S145 A146 K147 G14 V15 G16 K17 S18 A19 F29 D31 N117 K118 D120 L121 S146 A147 K148
BS02 0QY A K5 L6 V7 E37 D38 S39 D54 L56 T74 K6 L7 V8 E38 D39 S40 D55 L57 T75 MOAD: Kd=340uM
PDBbind-CN: -logKd/Ki=3.47,Kd=340uM
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding
Biological Process
GO:0007165 signal transduction
Cellular Component
GO:0016020 membrane

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Cellular Component
External links
PDB RCSB:4epy, PDBe:4epy, PDBj:4epy
PDBsum4epy
PubMed22566140
UniProtP01116|RASK_HUMAN GTPase KRas (Gene Name=KRAS)

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