Structure of PDB 4epw Chain A

Receptor sequence
>4epwA (length=170) Species: 9606 (Homo sapiens) [Search protein sequence]
GMTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGE
TCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQ
IKRVKDSEDVPMVLVGNKSDLPSRTVDTKQAQDLARSYGIPFIETSAKTR
QGVDDAFYTLVREIRKHKEK
3D structure
PDB4epw Discovery of Small Molecules that Bind to K-Ras and Inhibit Sos-Mediated Activation.
ChainA
Resolution1.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GDP A G13 G15 K16 S17 A18 F28 D30 N116 K117 D119 L120 S145 A146 K147 G14 G16 K17 S18 A19 F29 D31 N117 K118 D120 L121 S146 A147 K148
BS02 0QV A S39 D54 L56 Y71 T74 S40 D55 L57 Y72 T75 BindingDB: Kd=420000nM
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding
Biological Process
GO:0007165 signal transduction
Cellular Component
GO:0016020 membrane

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Cellular Component
External links
PDB RCSB:4epw, PDBe:4epw, PDBj:4epw
PDBsum4epw
PubMed22566140
UniProtP01116|RASK_HUMAN GTPase KRas (Gene Name=KRAS)

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