Structure of PDB 4ept Chain A

Receptor sequence
>4eptA (length=166) Species: 9606 (Homo sapiens) [Search protein sequence]
MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGET
CLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQI
KRVKDSEDVPMVLVGNKSDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQ
GVDDAFYTLVREIRKH
3D structure
PDB4ept Discovery of Small Molecules that Bind to K-Ras and Inhibit Sos-Mediated Activation.
ChainA
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GDP A G13 V14 G15 K16 S17 A18 F28 D30 E31 N116 K117 D119 L120 S145 A146 G13 V14 G15 K16 S17 A18 F28 D30 E31 N116 K117 D119 L120 S145 A146
BS02 0QW A K5 V7 D54 L56 Y71 K5 V7 D54 L56 Y71
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding
Biological Process
GO:0007165 signal transduction
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4ept, PDBe:4ept, PDBj:4ept
PDBsum4ept
PubMed22566140
UniProtP01116|RASK_HUMAN GTPase KRas (Gene Name=KRAS)

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