Structure of PDB 4ep2 Chain A

Receptor sequence
>4ep2A (length=198) Species: 11685 (HIV-1 M:B_ARV2/SF2) [Search protein sequence]
PQITLWKRPLVTIRIGGQLKEALLNTGADDTVLEEMNLPGKWKPKMIGGI
GGFIKVRQYDQIPVEILGHKAIGTVLVGPTPVNIIGRNLLTQIGMTLNFP
QITLWKRPLVTIRIGGQLKEALLNTGADDTVLEEMNLPGKWKPKMIGGIG
GFIKVRQYDQIPVEILGHKAIGTVLVGPTPVNIIGRNLLTQIGMTLNF
3D structure
PDB4ep2 Structural, kinetic, and thermodynamic studies of specificity designed HIV-1 protease.
ChainA
Resolution1.9 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) N125 T126 G127
Catalytic site (residue number reindexed from 1) N124 T125 G126
Enzyme Commision number 2.7.7.-
2.7.7.49: RNA-directed DNA polymerase.
2.7.7.7: DNA-directed DNA polymerase.
3.1.-.-
3.1.13.2: exoribonuclease H.
3.1.26.13: retroviral ribonuclease H.
3.4.23.16: HIV-1 retropepsin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A R8 N25 G27 A28 I47 G48 V82 R108 L123 N125 G127 D129 D130 I147 G148 P181 V182 R8 N25 G27 A28 I47 G48 V82 R107 L122 N124 G126 D128 D129 I146 G147 P180 V181
Gene Ontology
Molecular Function
GO:0004190 aspartic-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:4ep2, PDBe:4ep2, PDBj:4ep2
PDBsum4ep2
PubMed22549928
UniProtP03369|POL_HV1A2 Gag-Pol polyprotein (Gene Name=gag-pol)

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