Structure of PDB 4enz Chain A

Receptor sequence

>4enzA (length=1029) Species: 9606 (Homo sapiens)

KEKHYYIGIIETTWDYASDHGEKKLISVDTEHSNIYLQNGPDRIGRLYKK
ALYLQYTDETFRTTIEKPVWLGFLGPIIKAETGDKVYVHLKNLASRPYTF
HSHGITYYKEHEGAIYPDNTTDFQRADDKVYPGEQYTYMLLATEEQSPGE
GDGNCVTRIYHSHIDAPKDIASGLIGPLIICKKDSLDKEKEKHIDREFVV
MFSVVDENFSWYLEDNIKTYCSEPEKVDKDNEDFQESNRMYSVNGYTFGS
LPGLSMCAEDRVKWYLFGMGNEVDVHAAFFHGQALTNKNYRIDTINLFPA
TLFDAYMVAQNPGEWMLSCQNLNHLKAGLQAFFQVQECNKSSSKDNIRGK
HVRHYYIAAEEIIWNYAPSGIDIFTKENLTAPGSDSAVFFEQGTTRIGGS
YKKLVYREYTDASFTNRKERGPEEEHLGILGPVIWAEVGDTIRVTFHNKG
AYPLSIEPIGVRFNKNNEGTYYSPNVPPSASHVAPTETFTYEWTVPKEVG
PTNADPVCLAKMYYSAVDPTKDIFTGLIGPMKICKKGSLHANGRQKDVDK
EFYLFPTVFDENESLLLEDNIRMFTTAPDQVDKEDEDFQESNKMHSMNGF
MYGNQPGLTMCKGDSVVWYLFSAGNEADVHGIYFSGNTYLWRGERRDTAN
LFPQTSLTLHMWPDTEGTFNVECLTTDHYTGGMKQKYTVNQCRRQSEDST
FYLGERTYYIAAVEVEWDYSPQREWEKELHHLQEQNVSNAFLDKGEFYIG
SKYKKVVYRQYTDSTFRVPVERKAEEEHLGILGPQLHADVGDKVKIIFKN
MATRPYSIHAHGVQTESSTVTPTLPGETLTYVWKIPERSGAGTEDSACIP
WAYYSTVDQVKDLYSGLIGPLIVCRRPYNPRRKLEFALLFLVFDENESWY
LDDNIKTYSDHPEKVNKDDEEFIESNKMHAINGRMFGNLQGLTMHVGDEV
NWYLMGMGNEIDLHTVHFHGHSFQYKHRGVYSSDVFDIFPGTYQTLEMFP
RTPGIWLLHCHVTDHIHAGMETTYTVLQN

3D structure

• PDB: 4enz Ceruloplasmin: macromolecular assemblies with iron-containing acute phase proteins.
• Chain: A
• Resolution: 2.6 Å

Enzymatic activity

• Enzyme Commision number: 1.11.1.27: glutathione-dependent peroxiredoxin.
  1.11.1.9: glutathione peroxidase.
  1.16.3.1: ferroxidase.
  1.16.3.4: cuproxidase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	CU	A	H276 C319 H324	H276 C319 H324
BS02	CU	A	H163 H980 H1020	H163 H969 H1009
BS03	CU	A	H101 H103 H978	H101 H103 H967
BS04	CU	A	H103 H161 H1022	H103 H161 H1011
BS05	CU	A	H637 C680 H685	H630 C673 H678
BS06	CU	A	H975 C1021 H1026	H964 C1010 H1015
BS07	OXY	A	H101 H103 H161 H163 H978 H980 H1022	H101 H103 H161 H163 H967 H969 H1011
BS08	CA	A	K109 Q124 D127 D128	K109 Q124 D127 D128

Gene Ontology

Molecular Function

• GO:0005507 copper ion binding
• GO:0016491 oxidoreductase activity

External links

• PDB: RCSB:4enz, PDBe:4enz, PDBj:4enz
• PDBsum: 4enz
• PubMed: 23843990
• UniProt: P00450|CERU_HUMAN Ceruloplasmin (Gene Name=CP)