Structure of PDB 4emt Chain A

Receptor sequence
>4emtA (length=175) Species: 9606 (Homo sapiens) [Search protein sequence]
SVAHGLAWSYYIGYLRLILPELQARIRTYNQHYNNLLRGAVSQRLYILLP
LDCGVPDNLSMADPNIRFLDKLPQDRVYSNSIYELLENGQRAGTCVLEYA
TPLQTLFAMSQYSQAGFSREDRLEQAKLFCRTLEDILADAPESQNNCRLI
AYQEPADDSSFSLSQEVLRHLRQEE
3D structure
PDB4emt Structure of STING bound to cyclic di-GMP reveals the mechanism of cyclic dinucleotide recognition by the immune system.
ChainA
Resolution1.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 C2E A Y163 Y167 R238 T263 P264 Y10 Y14 R76 T101 P102 Manual survey: Kd=5uM (22728658)
MOAD: Kd=4.63uM
PDBbind-CN: -logKd/Ki=5.30,Kd~5uM
BindingDB: EC50=4500nM,Kd=1210nM
Gene Ontology
Biological Process
GO:0002218 activation of innate immune response
GO:0032481 positive regulation of type I interferon production

View graph for
Biological Process
External links
PDB RCSB:4emt, PDBe:4emt, PDBj:4emt
PDBsum4emt
PubMed22728658
UniProtQ86WV6|STING_HUMAN Stimulator of interferon genes protein (Gene Name=STING1)

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