Structure of PDB 4emd Chain A

Receptor sequence
>4emdA (length=299) Species: 561007 (Mycobacteroides abscessus ATCC 19977) [Search protein sequence]
GAVTVRAPGKVNLYLAVGDLRDDGYHELTTVFHAVSLADDVTVRDADVLS
IDVVGQGEGTVPTDERNLAWQAAELFADHVGRAPDVSIFINKDIPVAGGM
AGGSADAAAVLVAMNELWHAGVPRRDLHHLAAQLGSDVPFALHGGTALGT
GRGEQLATVLARNVFHWVFAFADGGLATPQVFKEIDRLRENGDPPRLAEA
DELLGALAAGDARRLAPLLGNELQAAAVSLNPELRRTLRAGESAGALAGI
VSGSGPTCAFLCTSADDAVQVSAELAGAGVCRTVRVASGPVHGAQVIQG
3D structure
PDB4emd Increasing the structural coverage of tuberculosis drug targets.
ChainA
Resolution1.75 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) K21 D148
Catalytic site (residue number reindexed from 1) K10 D137
Enzyme Commision number 2.7.1.148: 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 C5P A Y36 H37 S147 R163 F193 Y25 H26 S136 R152 F182
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0050515 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase activity
Biological Process
GO:0008299 isoprenoid biosynthetic process
GO:0016114 terpenoid biosynthetic process
GO:0016310 phosphorylation
GO:0019288 isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway

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Molecular Function
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Biological Process
External links
PDB RCSB:4emd, PDBe:4emd, PDBj:4emd
PDBsum4emd
PubMed25613812
UniProtB1MKD5

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