Structure of PDB 4el9 Chain A

Receptor sequence
>4el9A (length=290) Species: 10090 (Mus musculus) [Search protein sequence]
EIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYA
MKVLKKATLKVRDRVRDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGG
DLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDE
EGHIKLTDFGLSKESEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGV
LMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRN
PANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKP
3D structure
PDB4el9 Insights into the Inhibition of the p90 Ribosomal S6 Kinase (RSK) by the Flavonol Glycoside SL0101 from the 1.5 A Crystal Structure of the N-Terminal Domain of RSK2 with Bound Inhibitor.
ChainA
Resolution1.55 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D193 K195 E197 N198 D211 T231
Catalytic site (residue number reindexed from 1) D140 K142 E144 N145 D158 T175
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AFE A F79 K100 V131 L147 D148 L155 E197 L200 L214 F31 K52 V78 L94 D95 L102 E144 L147 L161 PDBbind-CN: -logKd/Ki=5.36,IC50=4.37uM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4el9, PDBe:4el9, PDBj:4el9
PDBsum4el9
PubMed22846040
UniProtP18654|KS6A3_MOUSE Ribosomal protein S6 kinase alpha-3 (Gene Name=Rps6ka3)

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