Structure of PDB 4ejx Chain A

Receptor sequence
>4ejxA (length=1034) Species: 9606 (Homo sapiens) [Search protein sequence]
KEKHYYIGIIETTWDYASDHGEKKLISVDTEHSNIYLQNGPDRIGRLYKK
ALYLQYTDETFRTTIEKPVWLGFLGPIIKAETGDKVYVHLKNLASRPYTF
HSHGITYYKEHEGAIYPDNTTDFQRADDKVYPGEQYTYMLLATEEQSPGE
GDGNCVTRIYHSHIDAPKDIASGLIGPLIICKKDSLDKEKEKHIDREFVV
MFSVVDENFSWYLEDNIKTYCSEPEKVDKDNEDFQQSNRMYSVNGYTFGS
LSGLSMCAEDRVKWYLFGMGNEVDVHAAFFHGQALTNKNYRIDTINLFPA
TLFDAYMVAQNPGEWMLSCQNLNHLKAGLQAFFQVQECNKSSSKDNIRGK
HVRHYYIAAEEIIWNYAPSGIDIFTKENLTAPGSDSAVFFEQGTTRIGGS
YKKLVYREYTDASFTNRKERGPEEEHLGILGPVIWAEVGDTIRVTFHNKG
AYPLSIEPIGVRFNKNNEGTYYSPNVPPSASHVAPTETFTYEWTVPKEVG
PTNADPVCLAKMYYSAVDPTKDIFTGLIGPMKICKKGSLHANGRQKDVDK
EFYLFPTVFDENESLLLEDNIRMFTTAPDQVDKEDEDFQESNKMHSMNGF
MYGNQPGLTMCKGDSVVWYLFSAGNEADVHGIYFSGNTYLWRGERRDTAN
LFPQTSLTLHMWPDTEGTFNVECLTTDHYTGGMKQKYTVNQCRRQSEDST
FYLGERTYYIAAVEVEWDYSPQREWEKELHHLQEQNVSNAFLDKGEFYIG
SKYKKVVYRQYTDSTFRVPVERKAEEEHLGILGPQLHADVGDKVKIIFKN
MATRPYSIHAHGVQTESSTVTPTLPGETLTYVWKIPERSGAGTEDSACIP
WAYYSTVDQVKDLYSGLIGPLIVCRRPYLKVFNPRRKLEFALLFLVFDEN
ESWYLDDNIKTYSDHPEKVNKDDEEFIESNKMHAINGRMFGNLQGLTMHV
GDEVNWYLMGMGNEIDLHTVHFHGHSFQYKHRGVYSSDVFDIFPGTYQTL
EMFPRTPGIWLLHCHVTDHIHAGMETTYTVLQNE
3D structure
PDB4ejx Ceruloplasmin: macromolecular assemblies with iron-containing acute phase proteins.
ChainA
Resolution4.69 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.11.1.27: glutathione-dependent peroxiredoxin.
1.11.1.9: glutathione peroxidase.
1.16.3.1: ferroxidase.
1.16.3.4: cuproxidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CU A H276 C319 H324 H276 C319 H324
BS02 CU A H163 H980 H1020 H163 H973 H1013
BS03 CU A H103 H161 H1022 H103 H161 H1015
BS04 CU A H101 H978 H980 H101 H971 H973
BS05 CU A H637 C680 H685 H630 C673 H678
BS06 CU A H975 C1021 H1026 M1031 H968 C1014 H1019 M1024
Gene Ontology
Molecular Function
GO:0005507 copper ion binding
GO:0016491 oxidoreductase activity

View graph for
Molecular Function
External links
PDB RCSB:4ejx, PDBe:4ejx, PDBj:4ejx
PDBsum4ejx
PubMed23843990
UniProtP00450|CERU_HUMAN Ceruloplasmin (Gene Name=CP)

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