Structure of PDB 4eip Chain A

Receptor sequence
>4eipA (length=521) Species: 68170 (Lentzea aerocolonigenes) [Search protein sequence]
PIETDVLILGGGPVGMALALDLAHRQVGHLVVDAGDGTITHPKVSTIGPR
SMELFRRWGVAKQIRTAGWPGDHPLDAAWVTRVGGHEVYRIPLGTADTRA
TPEHTPEPDAICPAHWLAPLLAEAVGERLRTRSRLDSFEQRDDHVRATIT
DLRTGATRAVHARYLVACDGASSPTRKALGIDAPPRHRTQVFRNILFRAP
ELRSLLGERAALVFFLMLSSSLRFPLRSLDGRGLYNLVVGVDDMDSFELV
RRAVAFDTEIEVLSDSEWHLTHRVADSFSAGRVFLTGDAAHTLSPSGGFG
MNTGIGSAADLGWKLAATLRGWAGPGLLATYEEERRPVAITSLEEANVNL
RRTMDRELPPGLHDDGPRGERIRAAVAEKLERSGARREFDAPGIHFGHTY
RSSIVCGEPETEVATGGWRPSARPGARAPHAWLTPTTSTLDLFGRGFVLL
SFGTTDGVEAVTRAFADRHVPLETVTCHAPEIHALYERAHVLVRPDGHVA
WRGDHLPAELGGLVDKVRGAA
3D structure
PDB4eip An Unusual Role for a Mobile Flavin in StaC-like Indolocarbazole Biosynthetic Enzymes.
ChainA
Resolution2.332 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) S48 L229 V241 P303
Catalytic site (residue number reindexed from 1) S45 L226 V238 P295
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 K2C A F227 P228 R230 P303 S304 G305 E396 F224 P225 R227 P295 S296 G297 E388
BS02 FAD A L12 G13 V17 D36 A37 V47 R137 D172 G173 D296 G306 G308 M309 N310 L9 G10 V14 D33 A34 V44 R134 D169 G170 D288 G298 G300 M301 N302 MOAD: Kd=20uM
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004497 monooxygenase activity
GO:0008168 methyltransferase activity
GO:0016491 oxidoreductase activity
GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
GO:0071949 FAD binding
Biological Process
GO:0032259 methylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4eip, PDBe:4eip, PDBj:4eip
PDBsum4eip
PubMed22840773
UniProtQ8KI25

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