Structure of PDB 4ehy Chain A

Receptor sequence
>4ehyA (length=307) Species: 224324 (Aquifex aeolicus VF5) [Search protein sequence]
FSYLYEKIINFRNTLYDKGFLKIKKLPVPVISVGNLSVGGSGKTSFVMYL
ADLLKDKRVCILSRGYKRKSKGTLIVSEYGNLKVSWEEAGDEPYLMAKLL
PHVSVVASEDRYKGGLLALEKLSPEVFILDDGFQHRKLHRDLNILLLKKK
DLKDRLLPAGNLREPLKEIRRADALVLTYQEVEPFEFFTGKPTFKMFREF
CCLLNSDFEEVPFDILKEREVIAFSGLGDNGQFRKVLKNLGIKVKEFMSF
PDHYDYSDFTPEEGEIYLTTPKDLIKLQGYENVFALNFKVKLEREEKLKK
LIYRIFY
3D structure
PDB4ehy Crystal structure of LpxK, the 4'-kinase of lipid A biosynthesis and atypical P-loop kinase functioning at the membrane interface.
ChainA
Resolution2.199 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.130: tetraacyldisaccharide 4'-kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP A G48 S49 K51 T52 S53 R206 F208 L235 G236 Q240 F241 T278 P279 K280 F296 G40 S41 K43 T44 S45 R198 F200 L227 G228 Q232 F233 T270 P271 K272 F288
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0009029 tetraacyldisaccharide 4'-kinase activity
GO:0016301 kinase activity
Biological Process
GO:0009244 lipopolysaccharide core region biosynthetic process
GO:0009245 lipid A biosynthetic process
GO:0016310 phosphorylation
Cellular Component
GO:0005886 plasma membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4ehy, PDBe:4ehy, PDBj:4ehy
PDBsum4ehy
PubMed22826246
UniProtO67572|LPXK_AQUAE Tetraacyldisaccharide 4'-kinase (Gene Name=lpxK)

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