Structure of PDB 4ege Chain A

Receptor sequence
>4egeA (length=371) Species: 362242 (Mycobacterium ulcerans Agy99) [Search protein sequence]
GRFDTAVYARRLAAAAAATEQAGLAGLVITPGYDLRYLIGSRADTFERLT
ALVLPASGVPTIVLPRLELASLKESAASDLGVCVRDWVDGDDPYQLVAVA
LGGAPAATAVTDSMPALHLLPLADALGVLPVLATDVLRQLRMVKEAAEVD
ALAKAGAAIDRVHARVPAFLVPGRTEAQVAADIAEAIVAEGHSAVAFVIV
GSGPHGADPHHGYSDRKLQVGDIVVVDIGGTYEPGYYSDSTRTYSIGDPS
PDVAQQYSALQRAQRAAVDAVRPGVTAAQVDAAARDVLADAGLAEYFVHR
TGHGIGLCVHEEPYIVAGNELPLVAGMAFSIEPGIYFPGRWGARIEDIVV
VTENGALSVNNRPHELMVVPV
3D structure
PDB4ege Increasing the structural coverage of tuberculosis drug targets.
ChainA
Resolution2.2 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H213 D230 D242 T244 H302 H306 H313 A331 E335 Y339 R347 E349
Catalytic site (residue number reindexed from 1) H210 D227 D239 T241 H299 H303 H310 A328 E332 Y336 R344 E346
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A D242 H306 E335 E349 D239 H303 E332 E346
BS02 ZN A D230 D242 E349 D227 D239 E346
BS03 ZN A D37 D115 D34 D112
Gene Ontology
Molecular Function
GO:0016787 hydrolase activity
GO:0046872 metal ion binding

View graph for
Molecular Function
External links
PDB RCSB:4ege, PDBe:4ege, PDBj:4ege
PDBsum4ege
PubMed25613812
UniProtA0PQS3

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