Structure of PDB 4ef4 Chain A

Receptor sequence
>4ef4A (length=178) Species: 9606 (Homo sapiens) [Search protein sequence]
NFNVAHGLAWSYYIGYLRLILPELQARIRTYNQHYNNLLRGAVSQRLYIL
LPLDCGVPDNLSMADPNIRFLDKLPQQRVYSNSIYELLENGQRAGTCVLE
YATPLQTLFAMSQYSQAGFSREDRLEQAKLFCRTLEDILADAPESQNNCR
LIAYQEPFSLSQEVLRHLRQEEKEEVTV
3D structure
PDB4ef4 Structural analysis of the STING adaptor protein reveals a hydrophobic dimer interface and mode of cyclic di-GMP binding
ChainA
Resolution2.147 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 C2E A Y167 T263 P264 Y16 T103 P104 Manual survey: Kd=4.42uM (22579474)
MOAD: Kd=4.42uM
PDBbind-CN: -logKd/Ki=5.35,Kd=4.42uM
BindingDB: EC50=4500nM,Kd=1210nM
BS02 CA A D205 E316 D54 E156 Manual survey: Kd=4.42uM (22579474)
Gene Ontology
Biological Process
GO:0002218 activation of innate immune response
GO:0032481 positive regulation of type I interferon production

View graph for
Biological Process
External links
PDB RCSB:4ef4, PDBe:4ef4, PDBj:4ef4
PDBsum4ef4
PubMed22579474
UniProtQ86WV6|STING_HUMAN Stimulator of interferon genes protein (Gene Name=STING1)

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