Structure of PDB 4eeq Chain A

Receptor sequence
>4eeqA (length=313) Species: 1351 (Enterococcus faecalis) [Search protein sequence]
PLTLTAATTRAQELRKQLNQYSHEYYVKDQPSVEDYVYDRLYKELVDIET
EFPDLITPDSPTQRVGGKVLSGFEKAPHDIPMYSLNDGFSKEDIFAFDER
VRKAIGKPVAYCCELKIDGLAISLRYENGVFVRGATRGDGTVGENITENL
RTVRSVPMRLTEPISVEVRGECYMPKQSFVALNEEREENGQDIFANPRNA
AAGSLRQLDTKIVAKRNLNTFLYTVADFGPMKAKTQFEALEELSAIGFRT
NPERQLCQSIDEVWAYIEEYHEKRSTLPYEIDGIVIKVNEFALQDELGFT
VKAPRWAIAYKFP
3D structure
PDB4eeq Design, Synthesis and Activity Evaluation of Potent NAD+ DNA Ligase Inhibitors as Potential Antibacterial Agents.
ChainA
Resolution2.1 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) E118 K120 D122 Y227 K315
Catalytic site (residue number reindexed from 1) E114 K116 D118 Y223 K311
Enzyme Commision number 6.5.1.2: DNA ligase (NAD(+)).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NMN A Y25 Y29 Y30 D39 Y42 D43 R158 Y21 Y25 Y26 D35 Y38 D39 R154
BS02 0OX A L89 K120 I121 Y227 K291 W310 L85 K116 I117 Y223 K287 W306
Gene Ontology
Molecular Function
GO:0003911 DNA ligase (NAD+) activity

View graph for
Molecular Function
External links
PDB RCSB:4eeq, PDBe:4eeq, PDBj:4eeq
PDBsum4eeq
PubMed
UniProtQ837V6|DNLJ_ENTFA DNA ligase (Gene Name=ligA)

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