Structure of PDB 4ed4 Chain A

Receptor sequence
>4ed4A (length=299) Species: 561007 (Mycobacteroides abscessus ATCC 19977) [Search protein sequence]
SDWVPTGAVTVRAPGKVNLYLAVGDLYHELTTVFHAVSLADDVTVRDADV
LSIDVVGQGEGTVPTDERNLAWQAAELFADHVGRAPDVSIFINKDIPVAG
GMAGGSADAAAVLVAMNELWHAGVPRRDLHHLAAQLGSDVPFALHGGTAL
GTGRGEQLATVLARNVFHWVFAFADGGLATPQVFKEIDRLRENGDPPRLA
EADELLGALAAGDARRLAPLLGNELQAAAVSLNPELRRTLRAGESAGALA
GIVSGSGPTCAFLCTSADDAVQVSAELAGAGVCRTVRVASGPVHGAQVI
3D structure
PDB4ed4 Increasing the structural coverage of tuberculosis drug targets.
ChainA
Resolution1.75 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) K21 D148
Catalytic site (residue number reindexed from 1) K16 D139
Enzyme Commision number 2.7.1.148: 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ATP A V72 N78 L79 K103 V107 A108 G110 A112 G113 G114 D117 D148 T189 V63 N69 L70 K94 V98 A99 G101 A103 G104 G105 D108 D139 T180
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0050515 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase activity
Biological Process
GO:0008299 isoprenoid biosynthetic process
GO:0016114 terpenoid biosynthetic process
GO:0016310 phosphorylation
GO:0019288 isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway

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Molecular Function
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Biological Process
External links
PDB RCSB:4ed4, PDBe:4ed4, PDBj:4ed4
PDBsum4ed4
PubMed25613812
UniProtB1MKD5

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