Structure of PDB 4ech Chain A

Receptor sequence
>4echA (length=489) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence]
SPAKKKVIIIGAGIAGLKAASTLHQNGIQDCLVLEARDRVGGRLQTVTGY
QGRKYDIGASWHQDTLTNPLFLEEAQLSLNDGRTRFVFDDDNFIYIDEER
GRVDHDKELLLEIVDNEMSKFAELEFHLGVSDCSFFQLVMKYLLQRRQFL
TNDQIRYLPQLCRYLELWHGLDWKLLSAKDTYFGHQGRNAFALNYDSVVQ
RIAQSFPQNWLKLSCEVKSITREPSKNVTVNCEDGTVYNADYVIITVPQS
VLNLSVQPEKNLRGRIEFQPPLKPVIQDAFDKIHFGALGKVIFEFEECCW
SNESSKIVTLANSTNEFVEIVRNAENLDELDSMLERSVTCWSQPLFFVNL
SKSTGVASFMMLMQAPLTNHIESIREDKERLFSFFQPVLNKIMKCLDSED
VIDGMANKPVLRNIIVSNWTRDPYSRGAYSACFPGDDPVDMVVAMSNGQD
SRIRFAGEHTIMDGAGCAYGAWESGRREATRISDLLKLE
3D structure
PDB4ech Mechanistic and structural analyses of the role of his67 in the yeast polyamine oxidase fms1.
ChainA
Resolution2.4 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Q67
Catalytic site (residue number reindexed from 1) Q63
Enzyme Commision number 1.5.3.17: non-specific polyamine oxidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FAD A G15 G17 A19 E39 A40 R41 G46 R47 G62 A63 W65 Q67 V223 V253 G270 L294 Y445 A449 Y450 G478 E479 G487 C488 A489 A492 G11 G13 A15 E35 A36 R37 G42 R43 G58 A59 W61 Q63 V217 V247 G264 L288 Y424 A428 Y429 G457 E458 G466 C467 A468 A471
Gene Ontology
Molecular Function
GO:0003682 chromatin binding
GO:0016491 oxidoreductase activity
GO:0046592 polyamine oxidase activity
GO:0050660 flavin adenine dinucleotide binding
GO:0052897 N8-acetylspermidine:oxygen oxidoreductase (propane-1,3-diamine-forming) activity
GO:0052901 spermine oxidase activity
GO:0052903 N(1)-acetylpolyamine oxidase (3-acetamidopropanal-forming) activity
Biological Process
GO:0006338 chromatin remodeling
GO:0015940 pantothenate biosynthetic process
GO:0046208 spermine catabolic process
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4ech, PDBe:4ech, PDBj:4ech
PDBsum4ech
PubMed22642831
UniProtP50264|FMS1_YEAST Polyamine oxidase FMS1 (Gene Name=FMS1)

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