Structure of PDB 4ebw Chain A

Receptor sequence
>4ebwA (length=259) Species: 9606 (Homo sapiens) [Search protein sequence]
STRDYEIQRERIELGRCIGEGQFGDVHQGIYMSNPALAVAIKTCKNCTSD
SVREKFLQEALTMRQFDHPHIVKLIGVITENPVWIIMELCTLGELRSFLQ
VRKYSLDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSSNDCVKL
GDFGLKLPIKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVK
NNDVIGRIENGERLPMPPNCPPTLYSLMTKCWAYDPSRRPRFTELKAQLS
TILEEEKAQ
3D structure
PDB4ebw Discovery and characterization of novel allosteric FAK inhibitors.
ChainA
Resolution2.65 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D546 A548 R550 N551 D564 K583
Catalytic site (residue number reindexed from 1) D134 A136 R138 N139 D152 K156
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 0PF A L534 L537 H544 R550 N551 L562 G563 D604 M607 L122 L125 H132 R138 N139 L150 G151 D177 M180 PDBbind-CN: -logKd/Ki=5.06,IC50=8.7uM
BindingDB: IC50=>30000nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4ebw, PDBe:4ebw, PDBj:4ebw
PDBsum4ebw
PubMed22819505
UniProtQ05397|FAK1_HUMAN Focal adhesion kinase 1 (Gene Name=PTK2)

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