Structure of PDB 4ead Chain A

Receptor sequence
>4eadA (length=440) Species: 83333 (Escherichia coli K-12) [Search protein sequence]
LFLAQEIIRKKRDGHALSDEEIRFFINGIRDNTISEGQIAALAMTIFFHD
MTMPERVSLTMAMRDSGTVLDWKSLHLNGPIVDKHSTGGVGDVTSLMLGP
MVAACGGYIPMISGRGLGHTGGTLDKLESIPGFDIFPDDNRFREIIKDVG
VAIIGQTSSLAPADKRFYATRDITATVDSIPLITASILAKKLAEGLDALV
MDVKVGSGAFMPTYELSEALAEAIVGVANGAGVRTTALLTDMNQVLASSA
GNAVEVREAVQFLTGEYRNPRLFDVTMALCVEMLISGKLAKDDAEARAKL
QAVLDNGKAAEVFGRMVAAQKGPTDFVENYAKYLPTAMLTKAVYADTEGF
VSEMDTRALGMAVVAMGGGRRQASDTIDYSVGFTDMARLGDQVDGQRPLA
VIHAKDENNWQEAAKAVKAAIKLADKAPESTPTVYRRISE
3D structure
PDB4ead Thymidine phosphorylase from E.coli with 3'-azido-2'-fluoro-dideoxyuridine
ChainA
Resolution1.5 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D83 K84 H85 S86 T123 D164 R171 S186 K190 K191
Catalytic site (residue number reindexed from 1) D83 K84 H85 S86 T123 D164 R171 S186 K190 K191
Enzyme Commision number 2.4.2.4: thymidine phosphorylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 0NP A T87 Y168 R171 V177 S186 K190 F210 T87 Y168 R171 V177 S186 K190 F210
Gene Ontology
Molecular Function
GO:0004645 1,4-alpha-oligoglucan phosphorylase activity
GO:0009032 thymidine phosphorylase activity
GO:0016154 pyrimidine-nucleoside phosphorylase activity
GO:0016757 glycosyltransferase activity
GO:0016763 pentosyltransferase activity
Biological Process
GO:0006206 pyrimidine nucleobase metabolic process
GO:0006213 pyrimidine nucleoside metabolic process
GO:0006974 DNA damage response
GO:0046104 thymidine metabolic process
Cellular Component
GO:0005829 cytosol
GO:0016020 membrane

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Biological Process
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Cellular Component
External links
PDB RCSB:4ead, PDBe:4ead, PDBj:4ead
PDBsum4ead
PubMed
UniProtP07650|TYPH_ECOLI Thymidine phosphorylase (Gene Name=deoA)

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