Structure of PDB 4ea3 Chain A

Receptor sequence
>4ea3A (length=278) Species: 562,9606 [Search protein sequence]
PLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALA
DTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSV
DRYVAICHPTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVE
IPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRLLSGSRE
KDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRF
CTALGYVNSCLNPILYAFLDENFKACFR
3D structure
PDB4ea3 Structure of the nociceptin/orphanin FQ receptor in complex with a peptide mimetic.
ChainA
Resolution3.013 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 0NN A Q107 I127 D130 Y131 M134 I219 S223 W276 Q280 V283 T305 Y309 Q61 I81 D84 Y85 M88 I166 S170 W223 Q227 V230 T252 Y256 PDBbind-CN: -logKd/Ki=9.57,IC50=0.27nM
Gene Ontology
Molecular Function
GO:0001626 nociceptin receptor activity
GO:0004930 G protein-coupled receptor activity
GO:0004985 G protein-coupled opioid receptor activity
GO:0005506 iron ion binding
GO:0009055 electron transfer activity
GO:0020037 heme binding
GO:0046872 metal ion binding
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
GO:0022900 electron transport chain
Cellular Component
GO:0016020 membrane
GO:0042597 periplasmic space

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Cellular Component
External links
PDB RCSB:4ea3, PDBe:4ea3, PDBj:4ea3
PDBsum4ea3
PubMed22596163
UniProtP0ABE7|C562_ECOLX Soluble cytochrome b562 (Gene Name=cybC);
P41146|OPRX_HUMAN Nociceptin receptor (Gene Name=OPRL1)

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