Structure of PDB 4e93 Chain A

Receptor sequence
>4e93A (length=361) Species: 9606 (Homo sapiens) [Search protein sequence]
SMIPEVQKPLHEQLWYHGAIPRAEVAELLVHSGDFLVRESQQEYVLSVLW
DGLPRHFIIQSLDNLYRLEGEGFPSIPLLIDHLLSTQQPLTKKSGVVLHR
AVPKDKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLP
PDLKAKFLQEARILKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTF
LRTEGARLRVKTLLQMVGDAAAGMEYLESKCCIHRDLAARNCLVTEKNVL
KISDFGMSREVPVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPY
PNLSNQQTREFVEKGGRLPCPELCPDAVFRLMEQCWAYEPGQRPSFSTIY
QELQSIRKRHR
3D structure
PDB4e93 Small-Molecule Inhibitors of the c-Fes Protein-Tyrosine Kinase.
ChainA
Resolution1.84 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D683 A685 R687 N688 D701
Catalytic site (residue number reindexed from 1) D236 A238 R240 N241 D254
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GUI A I567 R569 V575 A588 K590 M636 V639 G642 L690 I120 R122 V128 A141 K143 M189 V192 G195 L243 MOAD: ic50=45.8nM
PDBbind-CN: -logKd/Ki=6.93,IC50=118nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4e93, PDBe:4e93, PDBj:4e93
PDBsum4e93
PubMed22520759
UniProtP07332|FES_HUMAN Tyrosine-protein kinase Fes/Fps (Gene Name=FES)

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