Structure of PDB 4e92 Chain A

Receptor sequence
>4e92A (length=140) Species: 11676 (Human immunodeficiency virus 1) [Search protein sequence]
PIVQNLQGQMVHQAISPRTLNAWVKVVEEKAFSPEVIPMFSALSEGATPQ
DLNTMLNTVGGHQAAMQMLKETINEEAAEWDRLHPVHGQMREPRGSDIAG
TTSTLQEQIGWMTHNPPIPVGEIYKRWIILGLNKIVRMYS
3D structure
PDB4e92 Distinct Effects of Two HIV-1 Capsid Assembly Inhibitor Families That Bind the Same Site within the N-Terminal Domain of the Viral CA Protein.
ChainA
Resolution1.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.-
2.7.7.49: RNA-directed DNA polymerase.
2.7.7.7: DNA-directed DNA polymerase.
3.1.-.-
3.1.13.2: exoribonuclease H.
3.1.26.13: retroviral ribonuclease H.
3.4.23.16: HIV-1 retropepsin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 0OE A W80 E98 W117 H120 P122 I124 P125 R132 W80 E92 W111 H114 P116 I118 P119 R126
BS02 0OG A V27 A31 F32 S33 V36 V59 H62 I141 V27 A31 F32 S33 V36 V59 H62 I135
BS03 0OE A P34 E35 I37 P38 N139 P34 E35 I37 P38 N133
Gene Ontology

View graph for
Biological Process
External links
PDB RCSB:4e92, PDBe:4e92, PDBj:4e92
PDBsum4e92
PubMed22496222
UniProtP12497|POL_HV1N5 Gag-Pol polyprotein (Gene Name=gag-pol)

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