Structure of PDB 4e91 Chain A

Receptor sequence
>4e91A (length=131) Species: 11676 (Human immunodeficiency virus 1) [Search protein sequence]
PIVQVHQAISPRTLNAWVKVVEEKAFSPEVIPMFSALSEGATPQDLNTML
NTVGGHQAAMQMLKETINEEAAEWDRLHPVMREPRGSDIAGTTSTLQEQI
GWMTHNPPIPVGEIYKRWIILGLNKIVRMYS
3D structure
PDB4e91 Distinct Effects of Two HIV-1 Capsid Assembly Inhibitor Families That Bind the Same Site within the N-Terminal Domain of the Viral CA Protein.
ChainA
Resolution1.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.-
2.7.7.49: RNA-directed DNA polymerase.
2.7.7.7: DNA-directed DNA polymerase.
3.1.-.-
3.1.13.2: exoribonuclease H.
3.1.26.13: retroviral ribonuclease H.
3.4.23.16: HIV-1 retropepsin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 0OE A W80 E98 W117 H120 P122 I124 P125 I129 R132 W74 E83 W102 H105 P107 I109 P110 I114 R117
BS02 0OF A W23 V27 E28 A31 F32 S33 V36 V59 G60 G61 H62 A65 L138 W17 V21 E22 A25 F26 S27 V30 V53 G54 G55 H56 A59 L123
BS03 0OE A P34 I37 P38 N139 P28 I31 P32 N124
Gene Ontology

View graph for
Biological Process
External links
PDB RCSB:4e91, PDBe:4e91, PDBj:4e91
PDBsum4e91
PubMed22496222
UniProtP12497|POL_HV1N5 Gag-Pol polyprotein (Gene Name=gag-pol)

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