Structure of PDB 4e7j Chain A

Receptor sequence

>4e7jA (length=365) Species: 11963 (Human spumaretrovirus)

AELDQLLQGHYIKGYPKQYTYFLEDGKVKVSRPEGVKIIPPQSDRQKIVL
QAHNLAHTGREATLLKIANLYWWPNMRKDVVKQLGRCQQCLITNASNKAS
GPILRPDRPQKPFDKFFIDYIGPLPPSQGYLYVLVVVDGMTGFTWLYPTK
APSTSATVKSLNVLTSIAIPKVIHSDQGAAFTSSTFAEWAKERGIHLEFS
TPYHPQSSGKVERKNSDIKRLLTKLLVGRPTKWYDLLPVVQLALNNTYSP
VLKYTPHQLLFGIDSNTPFANQDTLDLTREEELSLLQEIRTSLYHPSTPP
ASSRSWSPVVGQLVQERVARPASLRPRWHKPSTVLKVLNPRTVVILDHLG
NNRTVSIDNLKPTSH

3D structure

• PDB: 4e7j 3'-Processing and strand transfer catalysed by retroviral integrase in crystallo.
• Chain: A
• Resolution: 3.1501 Å

Enzymatic activity

• Enzyme Commision number: 2.7.7.-
  2.7.7.49: RNA-directed DNA polymerase.
  2.7.7.7: DNA-directed DNA polymerase.
  3.1.-.-
  3.1.26.4: ribonuclease H.
  3.4.23.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	A	I112 L113 R114 P115 K124 E207 F208 S209 T210 Q215 S216 G218 K219 R222 D226 R229 S258 P259 N348 R350 T351	I103 L104 R105 P106 K115 E198 F199 S200 T201 Q206 S207 G209 K210 R213 D217 R220 S249 P250 N339 R341 T342
BS02	dna	A	P214 E221 R222 S225 K228 K262	P205 E212 R213 S216 K219 K253
BS03	dna	A	D128 P132 D185 Q186 G187 Y212 R329 R362	D119 P123 D176 Q177 G178 Y203 R320 R353
BS04	ZN	A	H62 H66 C99	H53 H57 C90

Gene Ontology

Molecular Function

• GO:0003676 nucleic acid binding

Biological Process

• GO:0015074 DNA integration

External links

• PDB: RCSB:4e7j, PDBe:4e7j, PDBj:4e7j
• PDBsum: 4e7j
• PubMed: 22580823
• UniProt: P14350|POL_FOAMV Pro-Pol polyprotein (Gene Name=pol)