Structure of PDB 4e73 Chain A

Receptor sequence
>4e73A (length=318) Species: 9606 (Homo sapiens) [Search protein sequence]
NNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKL
SRPFQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIV
MELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNI
VVKSDCTLKILDFGLARYYRAPEVILGMGYKENVDIWSVGCIMGEMIKGG
VLFPGTDHIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFE
KLFPDVLFPKASQARDLLSKMLVIDASKRISVDEALQHPYINVWYDPSEA
EREHTIEEWKELIYKEVM
3D structure
PDB4e73 Identification of an Adamantyl Azaquinolone JNK Selective Inhibitor.
ChainA
Resolution2.27 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) D151 K153 N156 D169
Catalytic site (residue number reindexed from 1) D144 K146 N149 D162
Enzyme Commision number 2.7.11.24: mitogen-activated protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A V118 M121 E126 R127 Y130 S161 D162 W324 E329 V111 M114 E119 R120 Y123 S154 D155 W294 E299
BS02 0NR A I32 G33 V40 A53 M108 E109 M111 D112 A113 V158 L168 I25 G26 V33 A46 M101 E102 M104 D105 A106 V151 L161 MOAD: ic50=0.049uM
BindingDB: IC50=49nM,EC50=21900nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004707 MAP kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4e73, PDBe:4e73, PDBj:4e73
PDBsum4e73
PubMed24900545
UniProtP45983|MK08_HUMAN Mitogen-activated protein kinase 8 (Gene Name=MAPK8)

[Back to BioLiP]