Structure of PDB 4e68 Chain A

Receptor sequence
>4e68A (length=559) Species: 10090 (Mus musculus) [Search protein sequence]
VVTEKQQMLEQHLQDVRKRVQDLEQKMKVVENLQDDFDFNYKTLKSQGDS
VTRQKMQQLEQMLTALDQMRRSIVSELAGLLSAMEYVQKTLTDEELADWK
RRQQIACIGGPPNICLDRLENWITSLAESQLQTRQQIKKLEELQQKVSYK
GDPIVQHRPMLEERIVELFRNLMKSAFVVERQPCMPMHPDRPLVIKTGVQ
FTTKVRLLVKFPELNYQLKIKVCIDKDSGDVAALRGSRKFNILGTNTKVM
NMEESNNGSLSAEFKHLTLREQRCGNGGRANCDASLIVTEELHLITFETE
VYHQGLKIDLETHSLPVVVISNICQMPNAWASILWYNMLTNNPKNVNFFT
KPPIGTWDQVAEVLSWQFSSTTKRGLSIEQLTTLAEKLLGPGVNYSGCQI
TWAKFCKENMAGKGFSFWVWLDNIIDLVKKYILALWNEGYIMGFISKERE
RAILSTKPPGTFLLRFSESSKEGGVTFTWVEKDISGSTQIQSVEPYTKQQ
LNNMSFAEIIMGYKIMDATNILVSPLVYLYPDIPKEEAFGKYCRAAPYLK
TKFICVTPF
3D structure
PDB4e68 Observation of unphosphorylated STAT3 core protein binding to target dsDNA by PEMSA and X-ray crystallography.
ChainA
Resolution2.585 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A R382 I431 V432 S465 Q469 R238 I287 V288 S321 Q325
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
GO:0007165 signal transduction

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4e68, PDBe:4e68, PDBj:4e68
PDBsum4e68
PubMed23434585
UniProtP42227|STAT3_MOUSE Signal transducer and activator of transcription 3 (Gene Name=Stat3)

[Back to BioLiP]