Structure of PDB 4e5u Chain A

Receptor sequence
>4e5uA (length=204) Species: 208964 (Pseudomonas aeruginosa PAO1) [Search protein sequence]
TGLFVTLEGPESTNRDYLAERLRERGIEVQLTREPGGTPLAERIRELLLA
PSDEPMAADTELLLMFAARAQHLAGVIRPALARGAVVLCDRFTDATYAYQ
GGGRGLPEARIAALESFVQGDLRPDLTLVFDLPVEIGLARAAARRLDRFE
QEDRRFFEAVRQTYLQRAAQAPERYQVLDAGLPLAEVQAGLDRLLPNLLE
RLNG
3D structure
PDB4e5u The crystal structure of thymidylate kinase from Pseudomonas aeruginosa PAO1 in complex with thymidine monophosphate.
ChainA
Resolution1.812 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.7.4.9: dTMP kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 TMP A E12 E39 P40 M70 R74 R96 A100 T101 Y104 Q105 F155 E11 E34 P35 M65 R69 R91 A95 T96 Y99 Q100 F149
BS02 CA A E12 E156 E11 E150
Gene Ontology
Molecular Function
GO:0004798 thymidylate kinase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
Biological Process
GO:0006227 dUDP biosynthetic process
GO:0006233 dTDP biosynthetic process
GO:0006235 dTTP biosynthetic process
GO:0009165 nucleotide biosynthetic process
GO:0016310 phosphorylation
GO:0046940 nucleoside monophosphate phosphorylation
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:4e5u, PDBe:4e5u, PDBj:4e5u
PDBsum4e5u
PubMed
UniProtQ9HZN8|KTHY_PSEAE Thymidylate kinase (Gene Name=tmk)

[Back to BioLiP]