Structure of PDB 4e2j Chain A

Receptor sequence

>4e2jA (length=246) Species: 32630 (synthetic construct) [Search protein sequence]

PTLISLLEVIEPEVLYSGYDSTLPDTSTRLMSTLNRLGGRQVVSAVKWAK
ALPGFRNLHLDDQMTLLQYSWMSLMAFSLGWRSYKQSNGNMLCFAPDLVI
NEERMQLPYMYDQCQQMLKISSEFVRLQVSYDEYLCMKVLLLLSTVPKDG
LKSQAVFDEIRMTYIKELGKAIVKREGNSSQNWQRFYQLTKLLDSMHEMV
GGLLQFCFYTFVNKSSVEFPEMLAEIISNQLPKFKAGSVKPLLFHQ

3D structure

PDB

4e2j Deciphering Modern Glucocorticoid Cross-pharmacology Using Ancestral Corticosteroid Receptors.

Chain

Resolution

2.5 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	A	V44 K48 M62 Q66 M221 E224	V46 K50 M64 Q68 M222 E225
BS02	MOF	A	M29 L32 N33 Q39 M70 M73 F92 M108 Q111 C112 M115 F204 C205 T208 F218	M31 L34 N35 Q41 M72 M75 F94 M110 Q113 C114 M117 F206 C207 T210 F219

External links

PDB	RCSB:4e2j, PDBe:4e2j, PDBj:4e2j
PDBsum	4e2j
PubMed	22437833

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