Structure of PDB 4e20 Chain A

Receptor sequence
>4e20A (length=282) Species: 10090 (Mus musculus) [Search protein sequence]
DPTVFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKEGCG
PQLRSGWQREIEILRTLYHEHIVKYKGCCEDSVQLVMEYVPLGSLRDYLP
RHCVGLAQLLLFAQQICEGMAYLHAQHYIHRALAARNVLLDNDRLVKIGD
FGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKECKFYYASDVWSFGVTL
YELLTYCDSNQSPHTKFTELIGQMTVLRLTELLERGERLPRPDRCPCEIY
HLMKNCWETEASFRPTFQNLVPILQTAQEKYQ
3D structure
PDB4e20 Enabling structure-based drug design of Tyk2 through co-crystallization with a stabilizing aminoindazole inhibitor.
ChainA
Resolution2.6 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) A1019 A1021 R1023 N1024 D1037 S1059
Catalytic site (residue number reindexed from 1) A132 A134 R136 N137 D150 S172
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 0MY A L899 G900 E901 G902 G905 K906 V907 A924 K926 Y976 V977 R1023 N1024 L1026 D1037 L16 G17 E18 G19 G22 K23 V24 A41 K43 Y89 V90 R136 N137 L139 D150 PDBbind-CN: -logKd/Ki=8.22,IC50=6nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4e20, PDBe:4e20, PDBj:4e20
PDBsum4e20
PubMed22995073
UniProtQ9R117|TYK2_MOUSE Non-receptor tyrosine-protein kinase TYK2 (Gene Name=Tyk2)

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