Structure of PDB 4e1n Chain A

Receptor sequence
>4e1nA (length=146) Species: 11698 (Human immunodeficiency virus type 1 (NEW YORK-5 ISOLATE)) [Search protein sequence]
CSPGIWQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLA
GRWPVKTVHTDNGSNFTSATVKAACWWAGIKQEFGIPNPQSQGVIESMNK
ELKKIIGQVRDQAEHLKTAVQMAVFIHNKKRKYSAGERIVDIIATD
3D structure
PDB4e1n New Class of HIV-1 Integrase (IN) Inhibitors with a Dual Mode of Action.
ChainA
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.-
2.7.7.49: RNA-directed DNA polymerase.
2.7.7.7: DNA-directed DNA polymerase.
3.1.-.-
3.1.13.2: exoribonuclease H.
3.1.26.13: retroviral ribonuclease H.
3.4.23.16: HIV-1 retropepsin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 TQX A Q168 A169 E170 H171 T174 M178 Q112 A113 E114 H115 T118 M122 MOAD: ic50=19nM
PDBbind-CN: -logKd/Ki=7.17,IC50=67nM
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
Biological Process
GO:0015074 DNA integration

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Molecular Function
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Biological Process
External links
PDB RCSB:4e1n, PDBe:4e1n, PDBj:4e1n
PDBsum4e1n
PubMed22535962
UniProtP12497|POL_HV1N5 Gag-Pol polyprotein (Gene Name=gag-pol)

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