Structure of PDB 4e0w Chain A

Receptor sequence
>4e0wA (length=254) Species: 10116 (Rattus norvegicus) [Search protein sequence]
NRSLIVTTLLEEPFVMFRKSDRTLYGNDRFEGYCIDLLKELAHILGFSYE
IRLVEDGKYGAQDDKGQWNGMVKELIDHKADLAVAPLTITHVREKAIDFS
KPFMTLGVSILYRKGTPIDSADDLAKQTKIEYGAVKDGATMTFFKKSKIS
TFEKMWAFMSSKPSALVKNNEEGIQRTLTADYALLMESTTIEYITQRNCN
LTQIGGLIDSKGYGIGTPMGSPYRDKITIAILQLQEEDKLHIMKEKWWRG
SGCP
3D structure
PDB4e0w Kainate induces various domain closures in AMPA and kainate receptors.
ChainA
Resolution2.3501 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 KAI A E15 Y63 P90 T92 R97 G142 A143 T144 E191 E11 Y59 P86 T88 R93 G138 A139 T140 E187 PDBbind-CN: -logKd/Ki=7.48,Ki=33nM
BindingDB: Ki=32.8nM
Gene Ontology
Molecular Function
GO:0015276 ligand-gated monoatomic ion channel activity
Cellular Component
GO:0016020 membrane

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Molecular Function
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Cellular Component
External links
PDB RCSB:4e0w, PDBe:4e0w, PDBj:4e0w
PDBsum4e0w
PubMed22425692
UniProtP42264|GRIK3_RAT Glutamate receptor ionotropic, kainate 3 (Gene Name=Grik3)

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