Structure of PDB 4dy7 Chain A

Receptor sequence
>4dy7A (length=45) Species: 9606 (Homo sapiens) [Search protein sequence]
EYQTFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYIDGR
3D structure
PDB4dy7 Crystal structures of protease nexin-1 in complex with heparin and thrombin suggest a 2-step recognition mechanism.
ChainA
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.5: thrombin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA A S14I D14L R15 S40 D43 R45
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation
Cellular Component
GO:0005576 extracellular region

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4dy7, PDBe:4dy7, PDBj:4dy7
PDBsum4dy7
PubMed22618708
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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