Structure of PDB 4dxc Chain A

Receptor sequence
>4dxcA (length=624) Species: 562,83333 [Search protein sequence]
KIEEGKLVIWINGDKGYNGLAEVGKKFEKDTGIKVTVEHPDKLEEKFPQV
AATGDGPDIIFWAHDRFGGYAQSGLLAEITPDKAFQDKLYPFTWDAVRYN
GKLIAYPIAVEALSLIYNKDLLPNPPKTWEEIPALDKELKAKGKSALMFN
LQEPYFTWPLIAADGGYAFKYENGKYDIKDVGVDNAGAKAGLTFLVDLIK
NKHMNADTDYSIAEAAFNKGETAMTINGPWAWSNIDTSKVNYGVTVLPTF
KGQPSKPFVGVLSAGINAASPNKELAKEFLENYLLTDEGLEAVNKDKPLG
AVALKSYEEELAKDPRRGSRGIIAALGPDGKPSRIVVIYTTGSQATMDER
NRQIAEIGASLIKHWGSGGGHPETLVKVKDAEDQLGARVGYIELDLNSGK
ILESFRPEERFPMMSTFKVLLCGAVLSRIDAGQEQLGRRIHYSQNDLVEY
SPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNM
GDHVTRLDRWEPELNEAIPNDERDTTMPVAMATTLRKLLTGELLTLASRQ
QLIDWMEADKVAGPLLRSALPSATMENAQKGEIMPNIPQMSAFWYAVRTA
VINAASGRQTVDEALKDAQTRITK
3D structure
PDB4dxc Structure of an Engineered beta-Lactamase Maltose Binding Protein Fusion Protein: Insights into Heterotropic Allosteric Regulation.
ChainA
Resolution2.3 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) S426 K429 S486 E522 N590 K593
Catalytic site (residue number reindexed from 1) S415 K418 S475 E511 N577 K580
Enzyme Commision number 3.5.2.6: beta-lactamase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A D164 H468 E477 D164 H457 E466
BS02 ZN A H509 H514 H498 H503
Gene Ontology
Molecular Function
GO:0008800 beta-lactamase activity
GO:0015144 carbohydrate transmembrane transporter activity
Biological Process
GO:0008643 carbohydrate transport
GO:0017001 antibiotic catabolic process
GO:0030655 beta-lactam antibiotic catabolic process
GO:0055085 transmembrane transport

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Molecular Function
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Biological Process
External links
PDB RCSB:4dxc, PDBe:4dxc, PDBj:4dxc
PDBsum4dxc
PubMed22720063
UniProtP0AEX9|MALE_ECOLI Maltose/maltodextrin-binding periplasmic protein (Gene Name=malE);
P62593|BLAT_ECOLX Beta-lactamase TEM (Gene Name=bla)

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