Structure of PDB 4dw4 Chain A

Receptor sequence
>4dw4A (length=161) Species: 268305 (Bovine viral diarrhea virus 1-CP7) [Search protein sequence]
ENITQWNLQDNGTEGIQRAMFQRGVNRSLHGIWPEKICTGVPSHLATDTE
LKAIHGMMDASEKTNYTCCRLQRHEWNKHGWCNWYNIEPWILLMNKTQAN
LTEGQPLRECAVTCRYDRDSDLNVVTQARDSPTPLTGCKKGKNFSFAGIL
VQGPCNFEIAV
3D structure
PDB4dw4 Crystal Structure of the Pestivirus Envelope Glycoprotein E(rns) and Mechanistic Analysis of Its Ribonuclease Activity.
ChainA
Resolution2.23 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.4.21.113: pestivirus NS3 polyprotein peptidase.
3.4.22.-
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
4.6.1.19: ribonuclease T2.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 U5P A W35 H76 E77 K80 H81 R131 W33 H74 E75 K78 H79 R129
BS02 U5P A N9 H32 A62 Q129 N7 H30 A60 Q127
BS03 U5P A L137 C140 K141 K142 L135 C138 K139 K140
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0033897 ribonuclease T2 activity

View graph for
Molecular Function
External links
PDB RCSB:4dw4, PDBe:4dw4, PDBj:4dw4
PDBsum4dw4
PubMed22579253
UniProtQ96662|POLG_BVDVC Genome polyprotein

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