Structure of PDB 4duh Chain A

Receptor sequence
>4duhA (length=195) Species: 83333 (Escherichia coli K-12) [Search protein sequence]
GLDAVRKRPGMYIGDTDDGTGLHHMVFEVVDNAIDEALAGHCKEIIVTIH
ADNSVSVQDDGRGIPTGIHPEEGVSAAEVIMTVLHAGGKFDDNSGVGVSV
VNALSQKLELVIQREGKIHRQIYEHGVPQAPLAVTGETEKTGTMVRFWPS
LETFTNVTEFEYEILAKRLRELSFLNSGVSIRLRDKRDGKEDHFH
3D structure
PDB4duh Structure-based discovery of substituted 4,5'-bithiazoles as novel DNA gyrase inhibitors.
ChainA
Resolution1.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 5.6.2.2: DNA topoisomerase (ATP-hydrolyzing).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 RLI A N46 E50 D73 R76 I78 P79 G101 K103 R136 V167 N32 E36 D59 R62 I64 P65 G87 K89 R114 V145 MOAD: Kd=6.6uM
PDBbind-CN: -logKd/Ki=5.18,Kd=6.6uM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005524 ATP binding
Biological Process
GO:0006265 DNA topological change

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Molecular Function
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Biological Process
External links
PDB RCSB:4duh, PDBe:4duh, PDBj:4duh
PDBsum4duh
PubMed22731783
UniProtP0AES6|GYRB_ECOLI DNA gyrase subunit B (Gene Name=gyrB)

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