Structure of PDB 4du7 Chain A

Receptor sequence
>4du7A (length=325) Species: 1282 (Staphylococcus epidermidis) [Search protein sequence]
GSMVKSGKARAHTNIALIKYWGKADETYIIPMNNSLSVTLDRFYTETKVT
FDPDFTEDCLILNGNEVNAKEKEKIQNYMNIVRDLAGNRLHARIESENYV
PTAAGLASSASAYAALAAACNEALSLNLSDTDLSRLARRGSGSASRSIFG
GFAEWEKGHDDLTSYAHGINSNGWEKDLSMIFVVIKKVSSRSGMSLTRDT
SRFYQYWLDHVDEDLNEAKEAVKNQDFQRLGEVIEANGLRMHATNLGAQP
PFTYLVQESYDAMAIVEQCRKANLPCYFTMDAGPNVKVLVEKKNKQAVME
QFLKVFDESKIIASDIISSGVEIIK
3D structure
PDB4du7 Structural basis for nucleotide binding and reaction catalysis in mevalonate diphosphate decarboxylase.
ChainA
Resolution2.201 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 4.1.1.33: diphosphomevalonate decarboxylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 DP6 A A14 Y18 W19 K21 S139 G140 S141 R144 S192 R193 M196 D283 A16 Y20 W21 K23 S141 G142 S143 R146 S190 R191 M194 D281
Gene Ontology
Molecular Function
GO:0004163 diphosphomevalonate decarboxylase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016829 lyase activity
GO:0016831 carboxy-lyase activity
Biological Process
GO:0006629 lipid metabolic process
GO:0008299 isoprenoid biosynthetic process
GO:0016310 phosphorylation
GO:0019287 isopentenyl diphosphate biosynthetic process, mevalonate pathway
Cellular Component
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4du7, PDBe:4du7, PDBj:4du7
PDBsum4du7
PubMed22734632
UniProtQ9FD73

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