Structure of PDB 4dsh Chain A

Receptor sequence

>4dshA (length=473) Species: 5693 (Trypanosoma cruzi) [Search protein sequence]

LLTPKIVIIGAGPTGLGAAVRLTELGYKNWHLYECNDTPGGLSRSFLDEN
GFTWDLGGHVIFSHYQYFDDVMDWAVQGWNVLQRESWVWVRGRWVPYPFQ
NNIHRLPEQDRKRCLDELVRSHARTYTEPPNNFEESFTRQFGEGIADIFM
RPYNFKVWAVPPCLMSTEWVEERVAPVDLERIRRNIQENRDDLGWGPNAT
FRFPQRGGTGIIYQAIKEKLPSEKLTFNSGFQAIAIDADAKTITFSNGEV
VSYDYLISTVPFDNLLRMTKGTGFKGYDEWPAIADKMVYSSTNVIGIGVK
GTPPPHLKTACWLYFPEDTSPFYRATVFSNYSKYNVPEGHWSLMLEVSES
KYKPVNHSTLIEDCIVGCLASNLLLPEDLLVSKWHYRIEKGYPTPFIGRN
NLLEKAQPELMSRCIYSRGRFGAWRYEVGNQDHSFMQGVEAIDHVLGLAT
EETTVANPGRVNGTRATTHFGLL

3D structure

PDB

4dsh Crystal Structures of Trypanosoma cruzi UDP-Galactopyranose Mutase Implicate Flexibility of the Histidine Loop in Enzyme Activation.

Chain

Resolution

2.25 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

5.4.99.9: UDP-galactopyranose mutase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	UDP	A	Y100 P101 F102 Q103 F152 N157 R176 Y317 R327 Y395 Y429	Y97 P98 F99 Q100 F149 N154 R173 Y314 R324 Y392 Y426
BS02	FDA	A	I12 G13 G15 P16 T17 E37 C38 N39 G44 L45 S46 L59 G61 H62 V63 Q235 A236 V263 G422 R423 G432 N433 Q434 S437	I9 G10 G12 P13 T14 E34 C35 N36 G41 L42 S43 L56 G58 H59 V60 Q232 A233 V260 G419 R420 G429 N430 Q431 S434

Gene Ontology

	Molecular Function
GO:0000166	nucleotide binding
GO:0016491	oxidoreductase activity

View graph for
Molecular Function

External links

PDB	RCSB:4dsh, PDBe:4dsh, PDBj:4dsh
PDBsum	4dsh
PubMed	22646091
UniProt	Q4E1W2

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