Structure of PDB 4dru Chain A

Receptor sequence
>4druA (length=549) Species: 420174 (Hepatitis C virus isolate HC-J4) [Search protein sequence]
SMSYTWTGALITPCAAEESKLPHHNMVYATTSRSASLRQKKVTFDRLQVL
DDHYRDVLKEMKAKASTVKAKLLSIEEACKLTPPHSAKSKFGYGAKDVRN
LSSRAVNHIRSVWEDLLEDTETPIDTTIMAKSEVFCVQGRKPARLIVFPD
LGVRVCEKMALYDVVSTLPQAVMGSSYGFQYSPKQRVEFLVNTWKSKKCP
MGFSYDTRCFDSTVTESDIRVEESIYQCCDLAPEARQAIRSLTERLYIGG
PLTNSKGQNCGYRRCRASGVLTTSCGNTLTCYLKATAACRAAKLQDCTML
VNGDDLVVICESAGTQEDAAALRAFTEAMTRYSAPPGDPPQPEYDLELIT
SCSSNVSVAHDASGKRVYYLTRDPTTPLARAAWETARHTPINSWLGNIIM
YAPTLWARMILMTHFFSILLAQEQLEKALDCQIYGACYSIEPLDLPQIIE
RLHGLSAFTLHSYSPGEINRVASCLRKLGVPPLRTWRHRARSVRAKLLSQ
GGRAATCGRYLFNWAVRTKLKLTPIPAASQLDLSGWFVAGYSGGDIYHS
3D structure
PDB4dru Structure-based macrocyclization yields hepatitis C virus NS5B inhibitors with improved binding affinities and pharmacokinetic properties.
ChainA
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.4.21.98: hepacivirin.
3.4.22.-
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 0LN A V37 A395 A396 H428 L492 V494 P495 W500 R503 V27 A381 A382 H414 L478 V480 P481 W486 R489 MOAD: Kd=2.4nM
PDBbind-CN: -logKd/Ki=8.62,Kd=2.4nM
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003968 RNA-dependent RNA polymerase activity
Biological Process
GO:0039694 viral RNA genome replication

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Molecular Function
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Biological Process
External links
PDB RCSB:4dru, PDBe:4dru, PDBj:4dru
PDBsum4dru
PubMed22473861
UniProtO92972|POLG_HCVJ4 Genome polyprotein

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