Structure of PDB 4drh Chain A

Receptor sequence
>4drhA (length=132) Species: 9606 (Homo sapiens) [Search protein sequence]
NNEESPTATVAEQGEDITSKKDRGVLKIVKRVGNGEETPMIGDKVYVHYK
GKLSNGKKFDSSHDRNEPFVFSLGKGQVIKAWDIGVATMKKGEICHLLCK
PEYAYGSAGSLPKIPSNATLFFEIELLDFKGE
3D structure
PDB4drh Large FK506-Binding Proteins Shape the Pharmacology of Rapamycin.
ChainA
Resolution2.3 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Y57 F67 D68 I87 Y113 F130
Catalytic site (residue number reindexed from 1) Y49 F59 D60 I79 Y105 F122
Enzyme Commision number 5.2.1.8: peptidylprolyl isomerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 RAP A Y57 F67 D68 H71 F77 G84 Q85 V86 I87 W90 Y113 F130 Y49 F59 D60 H63 F69 G76 Q77 V78 I79 W82 Y105 F122 BindingDB: Ki=3.0nM
Gene Ontology
Molecular Function
GO:0003755 peptidyl-prolyl cis-trans isomerase activity

View graph for
Molecular Function
External links
PDB RCSB:4drh, PDBe:4drh, PDBj:4drh
PDBsum4drh
PubMed23358420
UniProtQ13451|FKBP5_HUMAN Peptidyl-prolyl cis-trans isomerase FKBP5 (Gene Name=FKBP5)

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