Structure of PDB 4dqm Chain A

Receptor sequence
>4dqmA (length=234) Species: 9606 (Homo sapiens) [Search protein sequence]
PEVGELIEKVRKAHQETFPALCQLGKYTTNNSSEQRVSLDIDLWDKFSEL
STKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQ
DTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFANQLLPLEMDDAETGLLSA
ICLICGDRQDLEQPDRVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKI
TDLRSISAKGAERVITLKMEIPGSMPPLIQEMLE
3D structure
PDB4dqm Revealing a natural marine product as a novel agonist for retinoic acid receptors with a unique binding mode and inhibitory effects on cancer cells.
ChainA
Resolution2.75 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A K244 I258 P408 L409 E412 M413 K63 I77 P227 L228 E231 M232
BS02 LUF A F199 F228 C235 L269 I273 R276 F286 S287 F18 F47 C54 L88 I92 R95 F105 S106
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
GO:0048384 retinoic acid receptor signaling pathway
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4dqm, PDBe:4dqm, PDBj:4dqm
PDBsum4dqm
PubMed22642567
UniProtP10276|RARA_HUMAN Retinoic acid receptor alpha (Gene Name=RARA)

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